CXCL12 mRNA Expression as an Independent Marker of Liver Fibrogenesis in Rats

To date, the accumulated knowledge about role of CXCL12 chemokine in initiation and development liver fibrosis is scarce does not allow for assessing potential using mRNA level as an independent marker fibrogenesis processes associated with cirrhosis. A low expression (p < 0.0001) compared to control group rats was found when thioacetamide simulated cirrhosis male Wistar at all stages progression. An intensive decrease by 2.93 times revealed. The gene decreased gradually from 3 9 weeks. Reorganization parenchyma organ formation false hepatic nodules (11, 13, 15 weeks) were accompanied a change expression. There slight increase total pseudohepatic pronounced diffuse proliferation connective tissue (17 weeks). Our results suggest that can act but against background toxic damage it thioacetamide. When conducting fundamental, preclinical studies evaluate effectiveness antifibrotic drugs this experimental model dynamics pathological process, we consider three points minimum allowable number, namely, portal (3 weeks), bridging (5 beginning process transformation into (9